Dad’s Edema bibliography:
a first bibliography for edema by Dr. Heinz I Lippmann, MD


1. Brandstater ME, Roth EJ, Siebens HC: Venous thromboembolism in Stroke
      Literature Review and Implications for Clinical Practice, 
      Arch phys med rehabil 73-S: S-379-93, 1992. (81ref)
2. Merli GJ, Herbison GJ, DiTunno JF, Weitz HH, Henzes JH, Park CH,
      Jaweed MM: Deep Vein Thrombosis: Prophylaxis in Acute Spinal Cord        
      Injured Patients, Arch phys med rehabil 69(9): 661-4,1988 (36ref)
3. Kumar R, McKinney WP, Raj G, Perioperative Prophylaxis of Venous    
      Thromboembolism, Am J med sci 306: 336-44, 1993 (34 ref)
4. Merli GJ: UPDATE, Deep Vein Thrombosis and Pulmonary Embolism Pro-  
      phylaxis in Orthopedic Surgery  , Med Clin N Am, 77(2): 397-411,1993
5. Hoagland PM: Massive Pulmonary Embolism, in: Pulmonary Embolism and      
      Venous Thrombosis (Ed.S.Z.Goldhaber, Publ WB Saunders, Philadelphia   
       1985, pp 179-209 (175ref)
6. Warkentin TE, Levine MN, Hirsh J, Horsewood P(PhD), Roberts RS(med 
      tech), Gent M (D Sc), Kelton JG: Heparin-induced Thrombocytopenia
      in patients treated with low-molecular-weight heparin or unfract- 
      ionated heparin, New Engl J Med, 332(20): 1330-5, 1995 (38ref) 
7. Aster RH (M.B.): Heparin-Induced Thrombocytopenia and Thrombosis 
      (Ed), New Engl J Med, 332(20): 374-6, 1995 (11ref)
8. Safavi K, - Shojania AM,  -Schulman S, -Hirsh J (Letters to Ed): 
      Duration of Anticoagulant Therapy for Venous Thrombosis NEJM, 
      333(19):1288-9, 1995.
9.  Meythaler JM, DeVivo PhD MJ, Hayne Ja MSN: Cost-Effectiveness of            
      Routine Screening for Proximal Deep Venous Thrombosis in Acquired         
      Brain Injury Patients Admitted to Rehabilitation, 
        Arch phys med rehabi,77 (1): 1-5, (1996) (38ref)
10. Hales E: Pentoxyphyllin, the drug of the decade? J Am Acad Derm 30:
        639-42, 1994 (Ed)1
11. Kay R, Wong KS(MB,BS), YU YL, Chen YW(M.Med), Tsoi TH(M.Med),Ahuja
       AT, Chen  FL(MB.BS), Fong KY(MB.BS), Law CB(MB,ChB),Wong A (RN),
       Woo J,MD., Low-molecular weight heparin for the treatment of a,cute
       ischemic stroke, NEJM 333(24): 1588-93, 1995 (31ref)
12. Purewal T (MRCP), Watkins PJ (FRCP), Goss DE (BSC),Edmonds ME(FRCP)
       Lower limb venous pressure in diabetic neuropathy, Diab Care, 18:
       377-81, 1993 (16 ref). 

 B: Nitric Oxide References:
 100: Loscalzo J: Nitric oxide and Vascular Disease,(Ed), NEJM333(4):251-3
             1995. (15ref)
 101. Giaid A, Saleh D: Reduced Expression of endothelial Nitric Oxide Syn-     
             thase in the Lungs of Patients with Pulmonary Hypertension
              NEJM 333(4): 214-21, 1995 (37ref)
 102. Xue Ch, Johns R: Endothelial Nitric Oxide in the Lungs of Patients
             with Pulmonary Hypertension, NEJM 333(24): 1642-44, 1995
              (letter to Ed, with answer by 101.) (5ref)
  103. Lipton SA, Gendelman HI: Dementia associated with the acquired
              immuno-defficiency syndrome. NEJM. 332: 934-40, 1995.
  104. Fuchs D, Baier-Bitterlich G, Wachter H: Nitric Oxide and Aids
             Dementia, NEJM  333(8): 521-2, 1995 (letter to the Ed with 
             answer by 103) (5ref).
  105. Scherer U, Vollenweider L, Delabays A, Savcic M, Eichenberger U, 
             Kleger JR, Fikrle A, Ballmer PE, Nicod P, Bartsch P: Inhaled Nitric
             Oxide for High-Altitude Pulmonary Edema, NEJM 334(10):624-9,
             1996 (24ref).
  106.  Jerome EH, Severinghaus JW: High-Altitude Pulmonary Edema,
             NEJM 334(10) Editorial, 662-3, 1996 (15ref).
  107. Furchgott RF, Zawadski JV: The obligatory role of endothelial cells
             in the relaxation of arterial smooth muscle by acetylcholine,
             Nature 288: 373-6, 1980.
  108. Palmer RMJ, Ferrigr AG, Moncada S: Nitric oxide release accounts for
            the biological activity of endothelium-derived  relaxing factor,
            Nature 327: 524-6, 1987.
  109. Bredt DS, Snyder SH: Isolation of nitric oxide synthetase, a calmodu
              lin-requiring enzyme, Proc Nat Acad Sci USA 87: 682-5, 1990.
  110. Moncada S, Palmer RM, Higgs EA: Nitric Oxide: Physiology, patho-
              physiology, and pharmacology, Pharmacol Rev43: 109-42, 1991.           

 C. EDEMA-WATER References:

 252. Fullerton GD: Physiologic Basis of Magnetic Relaxation, Chapter 4
            in Stark&Bradley,jr  MRI, 2nd Ed, Mosby,NY
            88-119, 1992
 253. Nuclear Magnetic vResonance Techniques in Medicine (Davis Conf)
            Moderator Bradbury EM, Discussants Radda GK(PhD), Allen PS
            PHD, Ann Int Med 98:514-29, 1983.(57ref)
 254: Nuclear Magnetic Resonance (Editorial)  p 540-1by Baltaxe HA, 
           Geokas MC, MD,PhD, Davis, CA(23ref.)
 255. Phelps M, Mazziotta JC: Positron Emission Tomography: Human Brain
           Function and Biochemistry,  Science 228: 799-809, 1985(17May).
 256. Watterson JG: A role for water in cell structure, Biochem J 248:
           615-17, 1987 (brit!)
 257. Kuntz ID, Zipp A(PhDs): Water in Biological Systems, in “Physiology
           In Medicine” NEJM, 297(5), 262-6, 1977
 258. Ling GN, Walton CL:What Retains Water in Living Cells? 
           Science 191:293-5, 1976 (13 Jan)
 259. Yasumura S, Cohn SH, Ellis KJ: Measurement of extracellular space by
           total body neutron activation, Am J Physiol 244: (Regulatory
           Integrative Comp Phys.13), R36-40. 1983.
 260: Flynn MA(PhD), Hanna FM, Asfour RY, Lutz RN (PhD) : Estimation of
           Body Water Compartments of Preschool Children, Am J clin Nuttrit
           20(10): 1129-33, 1967.-II Undernourished Children.
 261. ORTHOPEDICS VOL 17(11) in toto, Nov 1994:
            a. Guest Editorial: MRI Techniques and Pract Appl
            b MRI of muscle injuries 991-9  (80ref)
            c MRI of Musculoskeletal tumors, 1003-16, (92 ref)
            d. MRI ofthe shoulder, 1021-8(40Ref)
            e. MRI of the elbow, 1029-35, (12ref)
            f. MRI of the wrist, 1041-8, (45 ref).
            g. MRI of the pelvis and hips 1053-62, (42ref)
            h. MRI of the knee, 1067-72, (30ref)
            i. MRI of the ankle and foot, 1075-82 (31 ref).
 262. Palmer BF: Nephrotic Edema-Pathogenesis and Treatment (South-
            western Internal Medicine Conf):  Am J Med Sci, 306(1): 53-67,
            1993 (109Ref)
 263. Clegg JS: Intracellular Water and the Cytomatrix: Some Methods of
           Study and Current Views, J Cell Biol 99:167s-71s, 1984 (40ref).
 264. Perico NM, Remuzzi G: Edema of the Nephrotic Syndrome: The Role of
           the Atrial Peptide System, Am J Kidn Dis 22(3): 355-66, 1993
 265. Meltzer Ji, Keim HJ, Laragh JH, Sealey JE(DSc), Jan KM, Chien SHU:
           Nephrotic Syndrome: Vasoconstriction and Hypervolemic Types
           Indicated by Renin-Sodium Profiling , Ann Int Med 91:688-96,1979
 266: Brown EA, Markandu ND, Sagnella GA, Squires M, Jones BE, MacGregor
           GA: Evidence that some Mechanism Other Than the Renin System
           Causes Sodium Retention in Nephrotic Syndrome, Lancet II(Dec4)
           1237-39, 1982 (11+ref).
 267. Lund T, Onarheim H, Reed RK (all Md-PhDs): Pathogenesis of Edema
           Formation in Burn Patients, W J Surg 16: 2-9, 1992(73ref)-”100”-
 268. Stokes JB, Grupp C, Kinne RKH: Purification of rat papillary
           collecting ductcells: functional and metabolic assessment  
          Am J Phys (renal Fluid Electrolye Phys 22) F251-F261,1987
 269. Aisen PS, Aisen ML: Shoulder-hand syndrome in cervical spinal cord 
           injury, Paraplegia32: 588-92, 1994 (17ref)-”102”-
 270. Putterman Ch, Barak V, Caraco Y, Neuman T, Shalit M: Episodic
           angioedema with eosinophilia: a case associated with T cell acti-
           vation and cytokine production, Ann Allergy 70: 243-8, 1993
           (21ref) -”103”-
 271. Henderson FC, Crockard HA, Stevens JM: Spinal cord oedema due to
           venous stasis, Neuroradiol 35: 312-25, 1993 (43ref)-”104”-
 272. Myerson MS, Henderson MR: Clinnical Applications of a pneumatic
           intermittent Impulse Compression Device after Trauma and Major
           Surgery to the foot and ankle, Foot&Ankle 14(4): 198-203,1993 
 273. Bates DO, Levick JR, Mortimer PS: Subcutaneous interstitial fluid
           pressure and arm volume in lymphoedema, Int J Microcirc 11:
          359-73, 1992 (33 ref)-”106”-
 274. Blackard WG: Edema-An infrequently recognized complication of
          bromocryptine and other ergot dopaminergic drugs, Am J Med
          94: 445, 1993 (4ref)-”107”-
 275. Bourne IHJ: Treatment of leg ulcers, J Royal Soc Med 85:1992(Dec)
          3 pages,  (13ref)-”108”-
 276. Buxbaum RE, Dennerli T, Weiss S, Heidemann SR: F-Actin and
          Microtubular Suspensions as undeterminate fluids, Science, 238?
          10 March, 1987, 1511-4.
 277.Witte MH,Jamal S, Williams WH, Witte Ch, Kumaswami V, McNeill GC,
          RT,Case TC, Panicker MP(PhD): Lymphatc abnormalities in Human
          Filariasis as Depicted by Lymphangioscintigraphy
          Arch Int Med 153:737-44, 1993.
 278. Lippmann HI: Anatomy and Physiology of Lymphatic System
           1963 manuscript -”130”- 
 279. Browman MW, LLitin SC, Binkowitz LA, Mohr DN: Pancreatic Pseudo-
           ocyst that compressed the inferior vena cava and resulted in edema
           of the lower extremities. Case Report. Mayo Clin Proc 67: 1085-8       
 280. Newhouse JH, Wiener N: Understanding MRI Ed Little Brown &Co
            Chapter 1,2,3,4,5,6,7,8,9, 10, 1991? 148 pages.  
 281. Eisenberg D, Kauzmann W: The Structure and Properties of Water,
            Oxford, the Clarendon Press, 1969 296 pages.
 282. Freischlag J, Machleder HI: Unilateral upper extremity edema, Case
            Report J Cardiovsc Surg 34(3): 251-4, 1993.
 283. Webster GF, Iozzo RV, Schwartzman RJ, Tahmoush AJ, Knobler RL,
           Jcooby RA: Reflex Sympathetic Dystrophy: Occurrence of chronic
           edema and nonimmune bulbous skin lesions, J Am Acad Dermat.,
           28: 29-32,1993. -”135”-.
 284. Bollinger A: Microlymphatics of human skin, Int J Microcirc:Clin
           Exper.12(1): 1-15, 1993.
 285. Ceyhan M: Scalp and facial edema preceding Schonlein-Henoch
            Ped Dermatol 9(3): 311, 1992
 286. McManus ML, Churchwell KB, Strange K: Regulation of cell volume in
            health and disease, (Review):NEJM 333(19):1260-6, 1995.
 287. Yarwood H,Nourshargh S,Brain S,Williams TJ: Effectofdexamethasone
            on neutrophil accumulation and oedema formation in rabbit skin:
            an investigation of site of action. Br J Pharmacol 108: 959-66,
            1993 -”111”-.
 288. Newbold P, Brain SD: The modulation  of inflammatory oedema by
             Calcitonin gene-related peptide,Br J Pharmacol 108:,705-101993.
 289. Warren,JB, Larkin SW,Coughlan LM,Kajekar R, Williams TJ: Pituitary
            adenylate cyclase activating polypeptide is a potent vasodilator
           and oedema potentiator in rabbit skin in VIVO, Br J Pharmacol 106:
            331-4, 1992. -”113”-.
 290. Starling EH: On the absorption of fluids from the connective tissue 
           spaces, J Phys 19: 312, 1896.
 291. Drinker CK: Lymph , in Ann NY Acad Sci, 46,8:807-18, 1946
 292. Epstein M et al: Characterization of the renin-aldosterone system
            in decompensated cirrhosis, Circ Res, 41: 818, 1977.  
 293. Thames MD: Neural control of renal function: Contribution of cardio-
            pulmonary baroreceptors to the control of the kidney, Fed Proc.
            37: 1209, 1977.
 294. Chaimowitz C et al: Mechanism of increased renal tubular sodium
            reabsorption  in cirrhosis, Am J Med 52: 198, 1972.
 295. Klingler EL et al: Renal function changes in cirrhosis of the liver, 
            Arch Int Med, 125: 1010, 1970.
 296. Maxwell MH, Kleeman CR, EDs, Clinical Disorders of Fluid and 
            Electrolyte Metabolism, 3rd Ed, New York, McGraw-Hill
 297. Maack T et al: Atrial natriuretic factor: Structure and functional
            properties, Kidney Int 27: 607-15, 1985.
 298. de Wardener HE: Natriuretic hormone  Cin Sci, 53: 1, 1977.
 299. Chonko AM et al: The role of renin and aldosterone in the salt
            retention of edema, Am J Med 63: 881, 1977.
 300. Rushmer RF: Cardiovascular Dynamics, 4th Ed, Publ.W.B.Saunders Co.
            Philadelphia,London, 1976, 550-9.
 301. Culebras JM et al: Total body water and the exchangeable hydrogen :
             2. A review of of comparative data from animals, based on isotope
             dilution and dessication with a report of new data from the rat,
             Am J Phys 232: R60: 1977.
 302. Fanestil DD,in Maxwell and Kleemans Clinical Disorders of Fluid and
             Electrolyte Metabolism, 5th Ed Rbt Narins, McGraw-Hill, 1994, 11. 
 303. Shuman CR, Learner N, Doane JH.jr.: The effect of ganglion blocking     
            agents in congestive heart failure, Am, Heart J 47: 623-31,1954..
 304. Hillmen  P, Lewis SM, Bessler M, Luzzatto L, Dach JV: Natural history
            of Paroxysmal Nocturnal Hemoglobinuria, NEJM 333(19):1253-58,
            1996.                                                  (“PNH”)
 305. Niermeyer S, Shaffer EM, Thilo E,Corbin C, Moore LG: Arterial oxygena
            tion and pulmonary arterial pressure in healthy neonates and
            infants at high altitude, J Pediatr 123:767-72, 1993.
 306. Sime F,Banchero N, Penaloza D, Gamboa R Cruz J, Marticorena E: Pul-
            monary hypertension in children born and living at high altitudes,
           Am J Cardiol 11: 143-9, 1963.
 307. Lockhart A, Saiag B: Altitude and the human pulmonary circulation
           Clin Sci 60: 599-605, 1981. 
 308. Hillmen P, Bessler M, Mason PJ, Watkins WM, Luzzatto L: Specific
          defect in N-acetylglucosamine incorporation in the biosynthesis
          in the glycosylphosphatidylinositol anchor in cloned cell lines from
          patients with paroxysmal nocturnal hemoglobinuria. Proc Natl Acad
          Sci U.S.A. 90:5272-6, 1993.

	1. A recent study demonstrated that edema control by Unna Boot compression (UB) accelerated the healing of ulcers in legs with chronic venous insufficiency (CVI) (1) in a large number of individuals in different age groups. This raised the question as to the physiologic mechanisms by which edema control impacts on the healing of venous stasis ulcers. 
	2. Like the leg muscle pump, an UB sets up a pumping sequence in an ambulating person by virtue of its non-elastic consistency which establishes a fixed-volume compartment around the limb, similarly to the fascia around the muscle, that makes it a “pump” (2).
	3. In a leg under the UB the pumping force is generated by the power that moves the ankle joint (the “ankle pump”(3)) due to its anatomically determined topical relationship of its skin fixed to the UB and its deep tissues during movements. In an arm, possessed with the diarthrodial metacarpo-phalangeal, wrist and elbow joints and covered by an UB, any limb motion, passive or active, empties edema.                              
	4. As a general rule, the power that moves an ankle or any diarthrodial joint covered by an UB generates pumping pressures (4).
	5. Legs with venous stasis ulcers due to CVI, in a standing position show a marked drop in arterial blood flow around the ulcers (5)
	6. Unpublished observations in small animals (rabbits and cats) had demonstrated that hind legs covered by an UB elicited steep increases in arterial inflow during passive movements (6).
	7. We plan to record changes in arterial perfusion in human legs covered by an UB during passive and active ankle motions, by use of the laser-doppler in constant-temperature rooms and measured topical skin temperatures (7) or else by measuring cutaneous oxygen tension, as against the needed number of controls in the actual protocol. 	

1. Lippmann HI, Fishman LM, Farrar RH, Bernstein RK and Zybert PA:
	Edema control in the management of disabling chronic venous 		insufficiency, Arch Phys Med & Rehabil 1994; 75,4: 436-41,    
2. Lippmann HI: The mechanical basis of supportive therapy in chronic 		venous insufficiency: I. The Ankle Pump. Zbl Phlebol, 1970; 9: 		77-85.
3. Lippmann HI: Briere JP: The physical basis of external support in chronic 	venous insufficiency, Arch Phys Med Rehabil,1971;52: 555-62.
4. Lippmann HI: Pressure and Force Measurement. A rpt of workshop May 		27-8, 1968, Nat Acad Sci, Attachment 5, 1-4, 1968.
5. Dodd HI et al: Skin oxygen tension in venous insufficiency in lower leg. , 		J Royal Soc Med , 1985, 78: 373-6 
6. Lippmann HI: Studies on reactive hyperemia (unpublished) at the Ciba-		Geigy research institute, Horsham, Sussex, May-July, 1970.
7. Winsor T et al: Influence of local and environmental temperatures on 		cutaneous circulation with use of laser doppler flowmetry, 		Angiology, 1989; 40.5: 421-8.
                                                 THE END

 309. Rosse WF:Dr.Ham’s test revisited: Blood 78: 547-50, 1990.

Dad, Professor of Rehabilitation Medicine Emeritus at Albert Einstein Medical School, and still teaching the residents at age 89 as he was dying of Mesothelioma, was struggling to learn computer language in the early 90’s at the time IT was itself just figuring out better operating systems. He had one of those clunky earlier models. It was an awkward time in 1996-98 for Apple computers when Dad was preparing his book on Edema, and knew he had a race with time.

    He died way before this book was developed medically, but in the process of needing computer help and always giving me viewings of his work, my interest was piqued in edema. We had discussion on the range of this work taking in earth waters and some of the introduction does mention planetary parameters.

    At the time I had no inkling of having diabetes or edema, calf, or ankle pump problems, or distorted rocker-bottom feet that came to me 4 years after his death. I had all his files on both our computers, and at his death discovered several file drawers with all his papers published, as well as a collection of his drawings, art & fabulous doodles. I knew all along I wanted to publish a book of his with my small press, but then I had no premonition of going back to school and doing a masters degree, nor of living in a tiny house in Lyons Colorado with no presses or papermaking facility. OP4 became my perfect venue to make a web version of a book for dad’s unfinished opus on edema, interlacing his art and doodles, which only touch on his endless jokemaking abilities.

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